性别：男
职称：教授、理学博士
邮编：450002
通信地址：郑州市文化路95号, 河南农业大学生命科学学院
邮箱地址：gqyang@yeah.net
1982年9月-1985年7月研究生毕业于南京农业大学兽医系并获得农学硕士学位；
1992年2月-1995年7月博士研究生毕业于中国农业大学生物学院动物生物化学专业，获理学博士学位。
国内工作经历：1985年8月-1992年2月任河南农业大学畜牧兽医系助教和讲师；
1995年7月-1997年3月和1999年8月-2002年3月任中国农业大学农业生物技术国家重点实验室研究人员，生物化学与分子生物学讲师和副教授。
国外研究经历：1997年4月-1999年3月在日本九州大学任日本学术振兴会博士后研究人员；
2002年3月-2005年10月在美国德州大学达拉斯西南医学中心任博士后研究人员，2006年6月-2009年12月任新加坡国家科技局(A*STAR)生物医学科学研究所代谢医学实验室高级研究员。2009年回国工作。
2. 动物基因工程在畜牧业生产中的应用。目前主要的研究内容是利用乳腺细胞系和纳米技术生产猪多价高效新型疫苗。为解决我国猪的重大传染病防治存在的问题，利用动物乳腺细胞系和纳米技术大量生产具有精确、微量、高效、纯化、安全和节省动物免疫潜力的新型多价高效疫苗。利用乳腺组织特异性启动子组建表达载体，控制多顺反子病毒基因在乳腺细胞系中高效表达；纯化后的产物进行免疫原性与保护性实验；利用纳米技术处理纯化的目的产物，研制出猪重大病毒性传染病新型多价高效疫苗。
1. Xiaomei Zhang, Ran Yang, Yan Jia, Demin Cai, Bo Zhou, Xiaoli Qu, Huihua Han, Liang Xu, Linfeng Wang, Yanan Yao, and Guoqing Yang(通讯作者). Hypermethylation of Specificity Protein 1 Binding Site Suppresses Hypothalamic Proopiomelanocortin in Neonates and May Contribute to Metabolic Disorders in Adults: Impact of Maternal Dietary Conjugated Linoleic Acids. Diabetes. 2014; 63(5):1475–1487..
2. Demin Cai, Hongji Li, Bo Zhou, Liqiang Han, Xiaomei Zhang, Guoyu Yang(通讯作者), Guoqing Yang(通讯作者). Conjugated linoleic acid supplementation caused reduction of perilipin1 and aberrant lipolysis in epididymal adipose tissue. Biochem Biophys Res Commun. 2012; 422(4):621-6.
3. Phing-How Lou, Guoqing Yang, Lu Huang, Yunxia Cui, Tiffany Pourbahrami, George K. Radda, Cai Li, and Weiping Han. Reduced Body Weight and Increased Energy Expenditure in Transgenic Mice Over-Expressing Soluble Leptin Receptor. PLoS One; 2010; 5(7): e11669.
4.Jia You , Yue Yu , Lei Jiang , Wenxia Li , Xinxin Yu , Lety Gonzalez , Guoqing Yang , Zunji Ke , Wenjun Li , Cai Li , Yong Liu. Deficient signaling through intracellular Tyr985 of leptin receptor confers susceptibility to adult-onset or diet-induced obesity. Molecular and cellular biology. 2010; Apr 30(7) 1650-1659.
5.Guoqing Yang, Chun-Yan Lim, Chao Li, Theolynn Go, Weihong Pan, Christian Bjorbaek, Xinmin Cao, George K. Radda*, Cai Li, Weiping Han. FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1. The Journal of Biological Chemistry 2009; 284(6):3719-27.
6. Lei Jiang, Jia You, Xinxin Yu, Lety Gonzalez, Yue Yu, Qiong Wang, Guoqing Yang, Wenjun Li, Cai Li, and Yong Liu. Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proceedings of the National Academy of Sciences. 2008; 105(47): 18619-18624.
7. Kaiying Guo, Julie E. McMinn, Thomas Ludwig, Yi-Hao Yu, Guoqing Yang, Lulu Chen, Daniella Loh, Cai Li, Streamson Chua, Jr. and Yiying Zhang. Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities. Endocrinology. 2007; 148(8): 3987-97.
8. Paul Cohen(第一作者), Guoqing Yang(第一作者), Xinxin Yu, Alexander A. Soukas, Cara S. Wolfish, Jeffrey M. Friedman, Cai, Li. Induction of leptin receptor expression in the liver by leptin and food deprivation. The Journal of Biological Chemistry. 2005; 280(11), 10034-10039.
9. Hongfei Ge, Guoqing Yang, Xinxin Yu, Tiffany Pourbahrami, and Cai Li. Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4. Journal of Lipid Research. 2004; 45, 2071-2079.
10. Guoqing Yang, Hongfei Ge, Ann Boucher, Xinxin Yu. and Cai Li. Modulation of Direct Leptin Signaling by Soluble Leptin Receptor. Molecular Endocrinology. 2004; 18(6), 1354-1362.
11. Hongfei Ge, Guoqing Yang, Lu Huang, Daniel L. Motola, Tiffany Pourbahrami, and Cai Li. Oligomerization and Regulated Processing of Angiopoietin-like Protein 4. The Journal of Biological Chemistry. 2004; 279(3), 2038-2045.
12.Yunxia Cui, Lu Huang, Florent Elefteriou, Guoqing Yang, John M. Shelton, Jerald E. Giles, Orhan K. Oz, Tiffany Pourbahrami, Christopher Y. H. Lu, James A. Richardson, Gerard Karsenty, and Cai Li. Essential Role of STAT3 in Body Weight and Glucose Homeostasis. Molecular and Cellular Biology. 2004; 24(1), 258-269.
13. Guoqing Yang and Noboru Fujihara. Long-term Proliferation of Chicken Primordial Germ Cells Cultured in Vitro. Journal of Reproduction and Development. 1999; 45(2), 161-166.
14. Guoqing Yang and Noboru Fujihara. Survival and Proliferation of Refined Chicken Circulating Primordial Germ Cells Cultured in Vitro. Journal of Reproduction and Development. 1999; 45(2), 177-181.
15. Guoqing Yang, Yunping Dai, Baoli Zhu, Yongfu Cheng and Shunzhang Qi. Cloning of 5'regulatory element of bovine b-lactoglobulin gene and its utilization in generation of mammy bioreactors. Science in China (Series C). 1996; 39 (6), 662-669.
