
性别:男
职称:副教授
通信地址:河南农业大学龙子湖校区
邮箱地址:huilin@henau.edu.cn
2018.3- 河南农业大学
2014.6-2017.12 美国加州大学戴维斯,博士后、副研究员
2011.6-2014.6 美国明尼苏达大学,博士后
2008.9-2011.6 中科院成都生物所,环境科学,博士
2005.9-2008.6 中科院成都有机化学所,有机化学,硕士
2001.9-2005.6 西北农林科技大学,应用化学,学士
(2)国家重点研发计划项目子课题:新型纤维寡/二糖磷酸化酶的挖掘及适配改造,2022.11-2027.10
(3)国家自然基金面上项目:苯乙烯单加氧酶催化烯丙基二级醇类环氧化的底物手性识别及环氧化立体控制机,2022.01-2025.12
(4)河南省自然基金面上项目:苯乙烯单加氧酶StyAB2催化烯烃反马氏不对称水合反应的催化机制研究,2020.01-2021.12
(5)河南省科技攻关项目:小麦玉米病害真菌产孢抑制剂的研究,2019.01-2020.12
迄今,已在Angewandte Chemie International Edition, ACS Catalysis, Chemical Science等国际著名SCI期刊上发表论文40余篇,申请或授权国家发明专利授权9项。
[2025]
47. Zhi-Pu Li, Lanteng Wang, Yan Liu, Xiao-Qiong Pei, M. Qaiser Fatmi, Zhuanglin Shen, Jian Zhao, Hui Lin*, Jiahai Zhou*, Zhong-Liu Wu*, Structural and Mechanistic Insight into the Enantioselectivity of (R)-Selective Styrene Monooxygenases: A Tug-of-War between Proximal and Distal Residues. Angewandte Chemie International Edition 2025, 64 (17), e202423117.
46. Yi He, Yafang Che, Zhi-Pu Li, Xiao-Qiong Pei, Yan Liu, Zhi-Yi Xiao, Chun-Xiu Liu, Na Wang, Hui Lin*, M. Qaiser Fatmi*, Zhong-Liu Wu*, SgStyA-Mediated Diastereospecific Epoxidation Of Limonene: Accessing Enantiopure cis- and trans-Limonene 1, 2-Epoxides. ACS Catalysis 2025, 13497-13506.
45. Yuanyuan Zhang, Hongmiao Yuan, Chuanqi Sun, Xixian Xu, Zonglin Li, Jianqiang Lin, Xin Song, Zhimin Li, Hui Lin*, Hongge Chen*, One-pot biotransformation of cellulose to amylose through multienzyme cascade with nucleoside diphosphate glucose as glycosyl donors. Carbohydrate Polymers 2025, 368, 124076.
44. Huiping Gong, Yafang Che, Zhengmiao Zhang, Hongge Chen, Xinyu Liu, Zhongliu Wu, Hui Lin*, Characterization of a novel Halothermothrix orenii cellodextrin phosphorylase and its application in cellotriose synthesis. Molecular Catalysis 2025, 586, 115447.
43. Zhen Zhang, Hua Li, Feiyu Dong, Hui Lin, Yanan Li, Kun Cheng, Hongge Chen, Involvement of the intracellular β-glucosidase BGL1B from in the regulation of lignocellulose-degrading enzymes' synthesis. Biotechnology for Biofuels and Bioproducts 2025;18(1):11.
[2024]
42. Hui Lin*, Shengyuan Fang, Hang Gao, Zhangyuan Qin, Donglin Fan, Na Li, Zhongliu Wu, Hongge Chen*, Mechanistic Insights into Enantiocontrolling of Styrene Monooxygenase-Catalyzed Epoxidation of Olefins. ACS Catalysis 2024, 14, 2246-2251.
41. Yifan Xu, Feiyu Dong, Ruoxin Wang, Maria Ajmal, Xinyu Liu, Hui Lin*, Hongge Chen*, Alternative Splicing Analysis of Lignocellulose-Degrading Enzyme Genes and Enzyme Variants in Aspergillus Niger. Applied Microbiology and Biotechnology 2024, 108, 302.
40. Na Li, Yuan Wang, Yinyin Meng, Yangyong Lv, Shuaibing Zhang, Shan Wei, Pingan Ma, Yuansen Hu*, Hui Lin*, Structural and Functional Characterization of a New Thermophilic-Like Oye from Aspergillus flavus. Applied Microbiology and Biotechnology 2024, 108, 134.
39. Hang Gao, Zhengmiao Zhang, Hongmiao Yuan, Linyu Liu, Hongge Chen, Hui Lin*, Rhamnolipid production from waste cooking oil by a newly isolated thermo- and salt-tolerant Pseudomonas aeruginosa GH01. World Journal of Microbiology & Biotechnology 2024, 40(12), 396.
[2023]
38. Maria Ajmal, Adil Hussain, Asad Ali, Hongge Chen, Hui Lin*, Strategies for Controlling the Sporulation in Fusarium spp. Journal of Fungi 2023, 9 (1), 10.
37. Yuanyuan Zhang, Yapeng Li, Hui Lin, Guotao Mao, Xiang Long, Xinyu Liu, Hongge Chen. Broadening the Substrate Specificity of Cellobiose Phosphorylase from Clostridium thermocellum for Improved Transformation of Cellodextrin to Starch. International Journal of Molecular Sciences 2023, 24 (19), 14452.
[2022]
36. Hui Lin*, Yinyin Meng, Na Li, Yanhong Tang, Shuang Dong, Zhong-Liu Wu, Cuilian Xu, Romas Kazlauskas*, Hongge Chen*, Enzymatic Enantioselective anti-Markovnikov Hydration of Aryl Alkenes. Angewandte Chemie International Edition 2022, 61 (32), e202206472.
35. Shuang Dong, Donglin Fan, Qian Liu, Yinyin Meng, Xinyu Liu, Sen Yang, Hui Lin*, Na Li*, Hongge Chen*, Enantioselectivity and key residue of Herbaspirillum huttiense monooxygenase in asymmetric epoxidation of styrenes. Applied Microbiology and Biotechnology 2022, 106, 2007-2015.
34. Fanfan Zhang, Shiwen Xia*, Hui Lin, Jiao Liu, Wenxin Huang, Microbial Proline Racemase–Proline Dehydrogenase Cascade for Efficient Production of d-proline and N-boc-5-hydroxy-l-proline from l-proline. Applied Biochemistry and Biotechnology 2022, 194 (9), 4135-4146.
[2021]
33. Hu Xiao, Shuang Dong, Yan Liu, Xiao-Qiong Pei, Hui Lin*, Zhong-Liu Wu*, A new clade of styrene monooxygenases for (R)-selective epoxidation. Catalysis Science & Technology 2021, 11 (6), 2195-2201.
32. Can Cui, Hui Lin*, Wu Pu, Chao Guo, Yan Liu, Xiaoqion Pei, Zhong-Liu Wu*, Asymmetric Epoxidation and Sulfoxidation Catalyzed by a New Styrene Monooxygenase from Bradyrhizobium. Applied Biochemistry and Biotechnology 2021, 193 (1), 65-78.
31. Yan Liu, Zi-Yi Li, Chao Guo, Can Cui, Hui Lin, Zhong-Liu Wu*, Enhancing the thermal stability of ketoreductase ChKRED12 using the FireProt web server. Process Biochemistry 2021, 101, 207-212.
30. Xinyu Liu, Huawei Hou, Yapeng Li, Sen Yang, Hui Lin, Hongge Chen*, Fusion of cellobiose phosphorylase and potato alpha-glucan phosphorylase facilitates substrate channeling for enzymatic conversion of cellobiose to starch. Preparative Biochemistry & Biotechnology 2021, 1-7.
29. 张凡凡, 夏仕文, 谢永芳, 刘姣, 林晖, 类产碱假单胞菌XW-40发酵-生物转化级联产生D-脯氨酸,分子催化 2021, 35(4), 328-34.
[2020]
28. Hui Lin, Jun Zhao, Qingqing Zhang, Shixiu Cui, Zhiliang Fan, Hongge Chen*, Chaoguang Tian*, Identification and Characterization of a Cellodextrin Transporter in Aspergillus niger. Frontiers in Microbiology 2020, 11, 145.
27. Hui Lin, Yanhong Tang, Shuang Dong, Ruibo Lang, Hongge Chen*, A new monooxygenase from Herbaspirillum huttiense catalyzed highly enantioselective epoxidation of allylbenzenes and allylic alcohols. Catalysis Science & Technology 2020, 10 (7), 2145-2151.
26. Dongdong Zhu, Xinyu Liu, Xia Xie, Sen Yang, Hui Lin, Hongge Chen*, Characteristics of a XIP-resistant xylanase from Neocallimastix sp. GMLF1 and its advantage in barley malt saccharification. International Journal of Food Science & Technology 2020, 55 (5), 2152-2160.
25. Jun Zhao, Dingchen Shi, Sen Yang, Hui Lin, Hongge Chen*, Identification of an intracellular beta-glucosidase in Aspergillus niger with transglycosylation activity. Applied Microbiology and Biotechnology 2020, 104 (19), 8367-8380.
24. Can Cui, Chao Guo, Hui Lin, Zhaoyun Ding, Yan Liu, Zhong-Liu Wu*, Functional characterization of an (R)-selective styrene monooxygenase from streptomyces sp. NRRL S-31. Enzyme and Microbial Technology 2020, 132, 109391.
[2019]
23. Huanan Zhu, Wei Lu, Hui Lin, Zhanglei Ju, Xinyu Liu, Hongge Chen*, Effects of intron retention on properties of beta-glucosidase in Aspergillus niger. Fungal biology 2019, 123(6), 465-70.
22. Weiyi Tao, Yi Wang, Eric Walters, Hui Lin, Shuang Li, He Huang, Takao Kasuga, Zhiliang Fan*, Homoethanol Production from Glycerol and Gluconate Using Recombinant Klebsiella oxytoca Strains. Applied and environmental microbiology 2019, 85(5), e02122-18.
Before [2018]
21. Hui Lin, Romas J. Kazlauskas*, Michael Travisano*, Developmental evolution facilitates rapid adaptation. Scientific Reports 2017, 7(1), 15891.
20. Hui Lin, Amanda Hildebrand, Takao Kasuga, Zhiliang Fan*, Engineering Neurospora crassa for cellobionate production directly from cellulose without any enzyme addition. Enzyme and Microbial Technology 2017, 99, 25-31.
19. Hui Lin, Michael Travisano, Romas J. Kazlauskas*, Experimental Evolution of Trichoderma citrinoviride for Faster Deconstruction of Cellulose. PLoS One 2016, 11(1), e0147024.
18. Hui Lin, Michael Travisano, Romas J. Kazlauskas*, The Fungus Trichoderma Regulates Submerged Conidiation Using the Steroid Pregnenolone. ACS Chemical Biology 2016, 11(9), 2568-2575.
17. Amanda Hildebrand, Edyta Szewczyk, Hui Lin, Takao Kasuga, Zhiliang Fan*, Engineering Neurospora crassa for improved cellobiose and cellobionate production. Applied and Environmental Microbiology 2015, 81(2), 597-603.
16. David M. Nedrud, Hui Lin, Gilsinia Lopez, Santosh K. Padhi, Graig A. Legatt, Romas J. Kazlauskas*, Uncovering divergent evolution of alpha/beta-hydrolases: a surprising residue substitution needed to convert Hevea brasiliensis hydroxynitrile lyase into an esterase. Chemical Science 2014, 5(11), 4265-4277.
15. 徐梦宇, 刘艳杰, 林晖, 张帅兵, 吴中柳*, 假单胞菌催化的碳碳双键不对称还原. 应用与环境生物学报 2014, 20(5), 798-803.
14. 邢晔, 刘艳, 张超, 林晖, 杨涛, 庄名扬, 吴中柳*, 中国白酒酿造物料中分离的酵母菌株在不对称羰基还原中的应用. 应用与环境生物学报 2013, 19(6), 1014-1019.
13. Yan-Jie Liu, Xiao-Qiong Pei, Hui Lin, Ping Gai, Yu-Chang Liu, Zhong-Liu Wu*, Asymmetric bioreduction of activated alkenes by a novel isolate of Achromobacter species producing enoate reductase. Applied Microbiology and Biotechnology 2012, 95 (3), 635-645.
12. Shi Wen Xia*, Hui Lin, Yong Zheng Chen, Preparation of (R)-2-chloro-1-(m-chlorophenyl)ethanol by Lipozyme TL IM-catalyzed second resolution. Chinese Chemical Letters 2012, 23(3), 289-292.
11. Hui Lin, De-Fang Tang, Ahmed Qaed Ahmed Ahmed, Yan Liu, Zhong-Liu Wu*, Mutations at the putative active cavity of styrene monooxygenase: enhanced activity and reversed enantioselectivity. Journal of Biotechnology 2012, 161(3), 235-241.
10. Hui Lin, Yan Liu, Zhong-Liu Wu*, Asymmetric epoxidation of styrene derivatives by styrene monooxygenase from Pseudomonas sp. LQ26: effects of α- and β-substituents. Tetrahedron: Asymmetry 2011, 22 (2), 134-137.
9. Hui Lin, Yan Liu, Zhong-Liu Wu*, Highly diastereo- and enantio-selective epoxidation of secondary allylic alcohols catalyzed by styrene monooxygenase. Chemical Communications 2011, 47(9), 2610-2612.
8. Hui Lin, Jing-Yuan Liu, Hai-Bo Wang, Abeer Ahmed Qaed Ahmed, Zhong-Liu Wu*, Biocatalysis as an alternative for the production of chiral epoxides: A comparative review. Journal of Molecular Catalysis B: Enzymatic 2011, 72 (3), 77-89.
7. Abeer Ahmed Qaed, Hui Lin, De-Fang Tang, Zhong-Liu Wu*, Rational design of styrene monooxygenase mutants with altered substrate preference. Biotechnology Letters 2011, 33 (3), 611-616.
6. Chuan-Gen Tang, Hui Lin, Chao Zhang, Zhang-Qin Liu, Tao Yang, Zhong-Liu Wu*, Highly enantioselective bioreduction of N-methyl-3-oxo-3-(thiophen-2-yl) propanamide for the production of (S)-duloxetine. Biotechnology Letters 2011, 33 (7), 1435-1440.
5. Hui Lin, Jing Qiao, Yan Liu, Zhong-Liu Wu*, Styrene monooxygenase from Pseudomonas sp. LQ26 catalyzes the asymmetric epoxidation of both conjugated and unconjugated alkenes. Journal of Molecular Catalysis B: Enzymatic 2010, 67 (3), 236-241.
4. Hui Lin, Yong-Zheng Chen, Xiao-Ying Xu, Shi-Wen Xia*, Li-Xin Wang, Preparation of key intermediates of adrenergic receptor agonists: Highly enantioselective production of (R)-α-halohydrins with Saccharomyces cerevisiae CGMCC 2.396. Journal of Molecular Catalysis B: Enzymatic 2009, 57 (1), 1-5.
3. Yongzheng Chen, Hui Lin, Xiaoying Xu, Shiwen Xia*, Lixin Wang, Preparation the Key Intermediate of Angiotensin-Converting Enzyme (ACE) Inhibitors: High Enantioselective Production of Ethyl (R)-2-Hydroxy-4-Phenylbutyrate with Candida boidinii CIOC21. Advanced Synthesis & Catalysis 2008, 350 (3), 426-430.
2. 林晖, 陈永正, 夏仕文*, 王立新, 微生物细胞催化还原苯甲酰丙酮合成(R)-/(S)-3-羟基-1-苯丁酮, 合成化学 2008, 16(4), 378-82.
1. Yongzheng Chen, Jinggang Xu, Xiaoying Xu, Yu Xia, Hui Lin, Shiwen Xia*, Lixin Wang, Enantiocomplementary preparation of (S)- and (R)-mandelic acid derivatives via α-hydroxylation of 2-arylacetic acid derivatives and reduction of α-ketoester using microbial whole cells. Tetrahedron: Asymmetry 2007, 18 (21), 2537-2540.
2. 《多学科交叉融合设计——面向生物工程及生物制药工厂设计》上册,清华大学出版社,2022,副主编.
1. Hui Lin, Meng-Yu Xu, Yan Liu, Zhong-Liu Wu*, Biocatalytic Epoxidation for Green Synthesis. In Green Biocatalysis, Patel, R. N., Ed. John Wiley & Sons, Inc.: 2016; pp 351-372. doi: 10.1002/9781118828083.ch13.
8. 林晖, 陈红歌, 龚会平, 刘新育, 王明道, 裴亚欣,一种纤维寡糖磷酸化酶 StCDP 及酶解制备葡萄糖-1-磷酸的方法,202410741154X,2024.
7. 陈红歌, 王明道, 夏国庆, 林晖, 楚梦晓, 朱华楠,一种磷酸二酯酶BSP、生物制剂及其应用,ZL202210139703.7,2023.
6. 林晖; 陈红歌; 唐燕红; 董爽; 杨森; 刘新育; 王旭 一种烯烃水合酶在制备伯醇中的应用. ZL201911214183.6, 2021.
5. 林晖; 陈红歌; 董爽; 唐燕红; 杨森 一种生物酶催化制备(S)-3-苯基-1,2-环氧丙烷及其衍生物的方法. ZL201910854053.2, 2021.
4. 吴中柳,刘艳杰,林晖;一株无色杆菌及其不对称催化还原碳碳双键的方法. 专利号: ZL201210004039.1;申请日: 2012.01.08;授权日: 2013.06.05.
3. 吴中柳,林晖,刘艳,乔婧;一种苯乙烯环氧化酶基因及其用途,专利号: ZL201010120969.4;申请日:2010.03.10,授权日:2014.09.17.
2. 吴中柳,汤传根,张超,杨涛,刘章琴,林晖;一株粘红酵母及其制备(S)-羟基丙酰胺的方法,专利号ZL201010509822.4;申请日:2010.10.15;授权日2014.03.12.
1. 夏仕文, 林晖, 陈永正, 方国兰, 陈义文, 徐红梅. 一种制备(S)-5-(4-氟苯基)-5-羟基-戊酸甲酯的生物酶拆分法,专利号: ZL201210039374.5, 授权日2014-05-14.