林晖

姓名：林晖
性别：男
职称：副教授
通信地址：河南农业大学龙子湖校区
邮箱地址：huilin@henau.edu.cn
2018.3-                 河南农业大学
2017.6-2017.12      加州大学戴维斯                  副研究员
2014.6-2017.6        加州大学戴维斯                  博士后
2011.6-2014.6        明尼苏达大学                     博士后
2008.9-2011.6        中科院成都生物所              理学博士
2005.9-2008.6        中科院成都有机化学所       理学硕士
2001.9-2005.6        西北农林科技大学              理学学士
蛋白质与酶工程、生物工程专业前沿进展、酶工程（研）、现代生化分离工程学（研）、生物制药工程（研）
新型生物催化剂的开发及在其合成高附加值化学品中的应用，生物代谢途径及酶的进化。
主持科研项目：
（1）国家重点研发计划项目子课题：秸秆制淀粉精准高效多酶催化体系创建及调控机制（2022YFC3401701），2022.11-2027.10
（2）国家自然基金面上项目：苯乙烯单加氧酶催化烯丙基二级醇类环氧化的底物手性识别及环氧化立体控制机（32171472），2022.01-2025.12
（3）河南省自然基金面上项目：苯乙烯单加氧酶StyAB2催化烯烃反马氏不对称水合反应的催化机制研究（202300410218），2020.01-2021.12
（4）河南省科技攻关项目：小麦玉米病害真菌产孢抑制剂的研究（192102110163），2019.01-2020.12

迄今，已在Angewandte Chemie International Edition, ACS Catalysis, Chemical Science等国际著名SCI期刊上发表论文40余篇；获国家发明专利授权8项。近5年发文章：
[2024]
1.  Hui Lin*, Shengyuan Fang, Hang Gao, Zhangyuan Qin, Donglin Fan, Na Li, Zhongliu Wu, Hongge Chen*, Mechanistic Insights into Enantiocontrolling of Styrene Monooxygenase-Catalyzed Epoxidation of Olefins. ACS Catalysis 2024, 14, 2246-2251.
2.  Yifan Xu, Feiyu Dong, Ruoxin Wang, Maria Ajmal, Xinyu Liu, Hui Lin*, Hongge Chen*, Alternative Splicing Analysis of Lignocellulose-Degrading Enzyme Genes and Enzyme Variants in Aspergillus Niger. Applied Microbiology and Biotechnology 2024, 108, 302.
3.  Na Li, Yuan Wang, Yinyin Meng, Yangyong Lv, Shuaibing Zhang, Shan Wei, Pingan Ma, Yuansen Hu*, Hui Lin*, Structural and Functional Characterization of a New Thermophilic-Like Oye from Aspergillus Flavus. Applied Microbiology and Biotechnology 2024, 108, 134.
[2023]
4.  Maria Ajmal, Adil Hussain, Asad Ali, Hongge Chen, Hui Lin*, Strategies for Controlling the Sporulation in Fusarium spp. Journal of Fungi 2023, 9 (1), 10.
5.  Yuanyuan Zhang, Yapeng Li, Hui Lin, Guotao Mao, Xiang Long, Xinyu Liu, Hongge Chen. Broadening the Substrate Specificity of Cellobiose Phosphorylase from Clostridium thermocellum for Improved Transformation of Cellodextrin to Starch. International Journal of Molecular Sciences 2023, 24 (19), 14452.
[2022]
6.  Hui Lin*, Yinyin Meng, Na Li, Yanhong Tang, Shuang Dong, Zhong-Liu Wu, Cuilian Xu, Romas Kazlauskas*, Hongge Chen*, Enzymatic Enantioselective anti-Markovnikov Hydration of Aryl Alkenes. Angewandte Chemie International Edition 2022, 61 (32), e202206472.
7.    Shuang Dong, Donglin Fan, Qian Liu, Yinyin Meng, Xinyu Liu, Sen Yang, Hui Lin*, Na Li*, Hongge Chen*, Enantioselectivity and key residue of Herbaspirillum huttiense monooxygenase in asymmetric epoxidation of styrenes. Applied Microbiology and Biotechnology 2022, 106, 2007-2015.
8. Fanfan Zhang, Shiwen Xia*, Hui Lin, Jiao Liu, Wenxin Huang, Microbial Proline Racemase–Proline Dehydrogenase Cascade for Efficient Production of d-proline and N-boc-5-hydroxy-l-proline from l-proline. Applied Biochemistry and Biotechnology 2022, 194 (9), 4135-4146.
[2021]
9.    Hu Xiao, Shuang Dong, Yan Liu, Xiao-Qiong Pei, Hui Lin*, Zhong-Liu Wu*, A new clade of styrene monooxygenases for (R)-selective epoxidation. Catalysis Science & Technology 2021, 11 (6), 2195-2201.
10.   Can Cui, Hui Lin*, Wu Pu, Chao Guo, Yan Liu, Xiaoqion Pei, Zhong-Liu Wu*, Asymmetric Epoxidation and Sulfoxidation Catalyzed by a New Styrene Monooxygenase from Bradyrhizobium. Appl Biochem Biotechnol 2021, 193 (1), 65-78.
11.   Yan Liu, Zi-Yi Li, Chao Guo, Can Cui, Hui Lin, Zhong-Liu Wu*, Enhancing the thermal stability of ketoreductase ChKRED12 using the FireProt web server. Process Biochemistry 2021, 101, 207-212.
12.   Xinyu Liu, Huawei Hou, Yapeng Li, Sen Yang, Hui Lin, Hongge Chen*, Fusion of cellobiose phosphorylase and potato alpha-glucan phosphorylase facilitates substrate channeling for enzymatic conversion of cellobiose to starch. Preparative Biochemistry & Biotechnology 2021, 1-7.
[2020]
13.   Hui Lin, Jun Zhao, Qingqing Zhang, Shixiu Cui, Zhiliang Fan, Hongge Chen*, Chaoguang Tian*, Identification and Characterization of a Cellodextrin Transporter in Aspergillus niger. Frontiers in Microbiology 2020, 11, 145.
14.   Hui Lin, Yanhong Tang, Shuang Dong, Ruibo Lang, Hongge Chen*, A new monooxygenase from Herbaspirillum huttiense catalyzed highly enantioselective epoxidation of allylbenzenes and allylic alcohols. Catalysis Science & Technology 2020, 10 (7), 2145-2151.
15.   Dongdong Zhu, Xinyu Liu, Xia Xie, Sen Yang, Hui Lin, Hongge Chen*, Characteristics of a XIP-resistant xylanase from Neocallimastix sp. GMLF1 and its advantage in barley malt saccharification. International Journal of Food Science & Technology 2020, 55 (5), 2152-2160.
16.   Jun Zhao, Dingchen Shi, Sen Yang, Hui Lin, Hongge Chen*, Identification of an intracellular beta-glucosidase in Aspergillus niger with transglycosylation activity. Applied Microbiology and Biotechnology 2020, 104 (19), 8367-8380.
17.   Can Cui, Chao Guo, Hui Lin, Zhaoyun Ding, Yan Liu, Zhong-Liu Wu*, Functional characterization of an (R)-selective styrene monooxygenase from streptomyces sp. NRRL S-31. Enzyme and Microbial Technology 2020, 132, 109391.
著作：
1.  Lin, H., Xu, M.-Y., Liu, Y. and Wu, Z.-L. (2016) Biocatalytic Epoxidation for Green Synthesis, in Green Biocatalysis (ed R. N. Patel), John Wiley & Sons, Inc, Hoboken, NJ. doi: 10.1002/9781118828083.ch13.
2.  《多学科交叉融合设计——面向生物工程及生物制药工厂设计》上册，清华大学出版社，202201，副主编.
3.  《多学科交叉融合设计——面向生物工程及生物制药工厂设计》下册, 清华大学出版社，202201，副主编.